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Osteoporosis, osteopenia and pathological fracture (PheCode 743)

near SUPT3H · rs227831

Where this position leads

Condition: Osteoporosis

rs227831 Condition: Osteoporosis Osteoporosis Condition rs227831 rs227831 near SUPT3H

What the study found

Who was studied 37,640 European ancestry cases, 391,860 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0554 lower (95% confidence interval 0.039-0.072); p = 4 × 10−12.

How common The A allele had a frequency of about 41% in the people studied.

Where it sits Chromosome 6, band 6p21.1 — between genes, 96.2 kb from SUPT3H.

What each result means

A/A Two copies of the version the research linked to Osteoporosis, osteopenia and pathological fracture (PheCode 743). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Osteoporosis, osteopenia and pathological fracture (PheCode 743). That is a smaller link than two copies.
G/G No copy of the version the research linked to Osteoporosis, osteopenia and pathological fracture (PheCode 743). This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs227831

What is rs227831?

rs227831 is a single position in the genome, in or near the near SUPT3H gene. Published research associates it with osteoporosis, osteopenia and pathological fracture (phecode 743). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs227831 linked to?

On MyGeneLog this position is linked to Osteoporosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs227831 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs227831 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Osteoporosis, osteopenia and pathological fracture (PheCode 743) (rs227831). MyGeneLog™. https://www.mygenelog.com/variants/rs227831

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