0 5113Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others3Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 5,371 European ancestry cases, 412,561 European ancestry controls, 314 East Asian ancestry cases, 178,375 East Asian ancestry controls.
The effect
Each copy of the G allele shifted the measure 0.125 higher (95% confidence interval 0.085-0.165); p = 1 × 10−9.
Where it sits Chromosome 2, band 2p16.1 — in an intron of PUS10.
What each result means
G/GTwo copies of the version the research linked to Ulcerative colitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Ulcerative colitis. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Ulcerative colitis. This is the starting point the study compared everyone against.
rs2278300 is a single position in the genome, in or near the PUS10 gene. Published research associates it with ulcerative colitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2278300 linked to?
On MyGeneLog this position is linked to Ulcerative Colitis. The research behind each link, and its sources, are set out on that condition page.
Does having rs2278300 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2278300 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 5113Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others3Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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