PRODH · rs2277834
Where this position leads
Condition: Blood Metabolite Levels
What the study found
Who was studied 1,954 Chinese ancestry individuals.
The effect Each copy of the T allele shifted the measure 0.259 higher (95% confidence interval 0.23-0.29); p = 1 × 10−63.
How common The T allele had a frequency of about 20% in the people studied.
Where it sits Chromosome 22, band 22q11.21 — in an intron of PRODH.
What ClinVar records
Classification
Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2021-06-19.
ClinVar record 1182668 NM_016335.6(PRODH):c.732+83G>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs2277834 is a single position in the genome, in or near the PRODH gene. Published research associates it with metabolite levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Blood Metabolite Levels. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Human molecular genetics 2020, PMID:31628463. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Metabolite levels (rs2277834). MyGeneLog™. https://www.mygenelog.com/variants/rs2277834