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Who was studied 480,842 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.008 lower (95% confidence interval 0.006-0.01); p = 2 × 10−12.
How common The T allele had a frequency of about 34% in the people studied.
Where it sits Chromosome 14, band 14q22.3 — in an intron of OTX2.
What each result means
G/GNo copy of the version the research linked to Alcohol consumption. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Alcohol consumption. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Alcohol consumption. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs2277499 is a single position in the genome, in or near the OTX2 gene. Published research associates it with alcohol consumption. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2277499 linked to?
On MyGeneLog this position is linked to Alcohol Consumption. The research behind each link, and its sources, are set out on that condition page.
Does having rs2277499 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2277499 come from?
GWAS Catalog, Nature human behaviour 2019, PMID:31358974. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 523Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others3Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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