Standard

Peak expiratory flow

near C17orf67 · rs227728

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 393,161 European ancestry individuals, 4,227 African ancestry individuals, 1,564 East Asian ancestry individuals, 4,270 South Asian ancestry individuals, 2,798 Hispanic or Latin American individuals.

The effect Each copy of the A allele shifted the measure 7.82 z score lower; p = 5 × 10⁻¹⁵.

How common The A allele had a frequency of about 33% in the people studied.

Where it sits Chromosome 17, band 17q22 — between genes, 92.4 kb from C17orf67.

What each result means

A/A Two copies of the version the research linked to Peak expiratory flow. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/T One copy of the version the research linked to Peak expiratory flow. That is a smaller link than two copies.

T/T No copy of the version the research linked to Peak expiratory flow. This is the starting point the study compared everyone against.

Source

Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Shrine N, Izquierdo AG, Chen J, Packer R, Hall RJ, Guyatt AL, Batini C, Thompson RJ, Pavuluri C, Malik V, Hobbs BD, Moll M

and 136 more — show all

Kim W, Tal-Singer R, Bakke P, Fawcett KA, John C, Coley K, Piga NN, Pozarickij A, Lin K, Millwood IY, Chen Z, Li L, Wijnant SRA, Lahousse L, Brusselle G, Uitterlinden AG, Manichaikul A, Oelsner EC, Rich SS, Barr RG, Kerr SM, Vitart V, Brown MR, Wielscher M, Imboden M, Jeong A, Bartz TM, Gharib SA, Flexeder C, Karrasch S, Gieger C, Peters A, Stubbe B, Hu X, Ortega VE, Meyers DA, Bleecker ER, Gabriel SB, Gupta N, Smith AV, Luan J, Zhao JH, Hansen AF, Langhammer A, Willer C, Bhatta L, Porteous D, Smith BH, Campbell A, Sofer T, Lee J, Daviglus ML, Yu B, Lim E, Xu H, O'Connor GT, Thareja G, Albagha OME, Suhre K, Granell R, Faquih TO, Hiemstra PS, Slats AM, Mullin BH, Hui J, James A, Beilby J, Patasova K, Hysi P, Koskela JT, Wyss AB, Jin J, Sikdar S, Lee M, May-Wilson S, Pirastu N, Kentistou KA, Joshi PK, Timmers PRHJ, Williams AT, Free RC, Wang X, Morrison JL, Gilliland FD, Chen Z, Wang CA, Foong RE, Harris SE, Taylor A, Redmond P, Cook JP, Mahajan A, Lind L, Palviainen T, Lehtimäki T, Raitakari OT, Kaprio J, Rantanen T, Pietiläinen KH, Cox SR, Pennell CE, Hall GL, Gauderman WJ, Brightling C, Wilson JF, Vasankari T, Laitinen T, Salomaa V, Mook-Kanamori DO, Timpson NJ, Zeggini E, Dupuis J, Hayward C, Brumpton B, Langenberg C, Weiss S, Homuth G, Schmidt CO, Probst-Hensch N, Jarvelin MR, Morrison AC, Polasek O, Rudan I, Lee JH, Sayers I, Rawlins EL, Dudbridge F, Silverman EK, Strachan DP, Walters RG, Morris AP, London SJ, Cho MH, Wain LV, Hall IP, Tobin MD

China Kadoorie Biobank Collaborative Group · Qatar Genome Program Research (QGPR) Consortium

Nature genetics · 2023 · PMID 36914875 · open access

Questions about rs227728

What is rs227728?

rs227728 is a single position in the genome, in or near the near C17orf67 gene. Published research associates it with peak expiratory flow. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs227728 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs227728 come from?

GWAS Catalog, Nature genetics 2023, PMID:36914875. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Peak expiratory flow (rs227728). MyGeneLog™. https://www.mygenelog.com/variants/rs227728

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