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Pulmonary function

ADAM19 · rs2277027

Where this position leads

Condition: Pulmonary Function (Lung Capacity)

rs2277027 Condition: Pulmonary Function (Lung Capacity) Pulmonary Function (Lung Capacity) Condition rs2277027 rs2277027 ADAM19

What the study found

Who was studied 20,890 European ancestry individuals; replicated in 16,178 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.38 % higher; p = 1 × 10−10.

How common The A allele had a frequency of about 71% in the people studied.

Where it sits Chromosome 5, band 5q33.3 — in an intron of ADAM19.

What each result means

A/A Two copies of the version the research linked to Pulmonary function. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Pulmonary function. That is a smaller link than two copies.
C/C No copy of the version the research linked to Pulmonary function. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs2277027

What is rs2277027?

rs2277027 is a single position in the genome, in or near the ADAM19 gene. Published research associates it with pulmonary function. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2277027 linked to?

On MyGeneLog this position is linked to Pulmonary Function (Lung Capacity). The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs2277027?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs2277027 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2277027 come from?

GWAS Catalog, Nat Genet 2009, PMID:20010835. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Pulmonary function (rs2277027). MyGeneLog™. https://www.mygenelog.com/variants/rs2277027

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