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Asthma

OVOL1 · rs2276133

Where this position leads

Condition: Asthma

What the study found

Who was studied 139 Middle Eastern ancestry cases, 1,434 Middle Eastern ancestry controls, 4,069 Admixed American ancestry cases, 14,104 Admixed American ancestry controls, 4,015 South Asian ancestry cases, 27,091 South Asian ancestry controls, 5,051 African ancestry cases, 27,607 African ancestry controls, 18,549 East Asian ancestry cases, 322,655 East Asian ancestry controls, 121,940 European ancestry cases, 1,254,131 European ancestry controls; replicated in 180 Admixed American ancestry cases, 1,325 Admixed American ancestry controls, 2,455 African ancestry cases, 7,542 African ancestry controls, 1,375 Middle Eastern ancestry cases, 12,684 Middle Eastern ancestry controls, 5,981 European ancestry cases, 42,054 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0302 lower (95% confidence interval 0.021-0.04); p = 2 × 10⁻¹⁰.

How common The A allele had a frequency of about 28% in the people studied.

Where it sits Chromosome 11, band 11q13.1 — in an intron of OVOL1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Asthma compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Asthma.

G/G Published research associates this genotype with typical/baseline likelihood of Asthma — no copies of the reported risk allele.

Source

Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease

Zhou W, Kanai M, Wu KH, Rasheed H, Tsuo K, Hirbo JB, Wang Y, Bhattacharya A, Zhao H, Namba S, Surakka I, Wolford BN

and 140 more — show all

Lo Faro V, Lopera-Maya EA, Läll K, Favé MJ, Partanen JJ, Chapman SB, Karjalainen J, Kurki M, Maasha M, Brumpton BM, Chavan S, Chen TT, Daya M, Ding Y, Feng YA, Guare LA, Gignoux CR, Graham SE, Hornsby WE, Ingold N, Ismail SI, Johnson R, Laisk T, Lin K, Lv J, Millwood IY, Moreno-Grau S, Nam K, Palta P, Pandit A, Preuss MH, Saad C, Setia-Verma S, Thorsteinsdottir U, Uzunovic J, Verma A, Zawistowski M, Zhong X, Afifi N, Al-Dabhani KM, Al Thani A, Bradford Y, Campbell A, Crooks K, de Bock GH, Damrauer SM, Douville NJ, Finer S, Fritsche LG, Fthenou E, Gonzalez-Arroyo G, Griffiths CJ, Guo Y, Hunt KA, Ioannidis A, Jansonius NM, Konuma T, Lee MTM, Lopez-Pineda A, Matsuda Y, Marioni RE, Moatamed B, Nava-Aguilar MA, Numakura K, Patil S, Rafaels N, Richmond A, Rojas-Muñoz A, Shortt JA, Straub P, Tao R, Vanderwerff B, Vernekar M, Veturi Y, Barnes KC, Boezen M, Chen Z, Chen CY, Cho J, Smith GD, Finucane HK, Franke L, Gamazon ER, Ganna A, Gaunt TR, Ge T, Huang H, Huffman J, Katsanis N, Koskela JT, Lajonchere C, Law MH, Li L, Lindgren CM, Loos RJF, MacGregor S, Matsuda K, Olsen CM, Porteous DJ, Shavit JA, Snieder H, Takano T, Trembath RC, Vonk JM, Whiteman DC, Wicks SJ, Wijmenga C, Wright J, Zheng J, Zhou X, Awadalla P, Boehnke M, Bustamante CD, Cox NJ, Fatumo S, Geschwind DH, Hayward C, Hveem K, Kenny EE, Lee S, Lin YF, Mbarek H, Mägi R, Martin HC, Medland SE, Okada Y, Palotie AV, Pasaniuc B, Rader DJ, Ritchie MD, Sanna S, Smoller JW, Stefansson K, van Heel DA, Walters RG, Zöllner S, Martin AR, Willer CJ, Daly MJ, Neale BM

Cell genomics · 2022 · PMID 36777996 · open access

Questions about rs2276133

What is rs2276133?

rs2276133 is a single position in the genome, in or near the OVOL1 gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2276133 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs2276133 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2276133 come from?

GWAS Catalog, Cell genomics 2022, PMID:36777996. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Asthma (rs2276133). MyGeneLog™. https://www.mygenelog.com/variants/rs2276133

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