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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied up to 3,574 European ancestry individuals; replicated in up to 3,184 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.265 higher (95% confidence interval 0.23-0.30); p = 2 × 10−65.
How common The C allele had a frequency of about 6% in the people studied.
Where it sits Chromosome 9, band 9p21.2 — in an intron of TEK.
What each result means
A/ANo copy of the version the research linked to Endothelial growth factor levels. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Endothelial growth factor levels. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Endothelial growth factor levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs2273720 is a single position in the genome, in or near the Tie-2 gene. Published research associates it with endothelial growth factor levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2273720 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2273720 come from?
GWAS Catalog, Circulation. Cardiovascular genetics 2015, PMID:25552591. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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