Sensitive

Prostate cancer

LACE1 · rs2273669

Where this position leads

What the study found

Who was studied 11,085 European ancestry cases, 11,463 European ancestry controls; replicated in 19,662 European ancestry cases, 19,715 European ancestry controls.

The effect Each copy of the G allele carried 1.07 times the odds of Prostate cancer (95% confidence interval 1.03-1.11); p = 8 × 10⁻⁹.

How common The G allele had a frequency of about 15% in the people studied.

Where it sits Chromosome 6, band 6q21 — in an intron of ARMC2.

What each result means

A/A No copy of the version the research linked to Prostate cancer. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Prostate cancer. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Prostate cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

Eeles RA, Olama AA, Benlloch S, Saunders EJ, Leongamornlert DA, Tymrakiewicz M, Ghoussaini M, Luccarini C, Dennis J, Jugurnauth-Little S, Dadaev T, Neal DE

and 132 more — show all

Hamdy FC, Donovan JL, Muir K, Giles GG, Severi G, Wiklund F, Gronberg H, Haiman CA, Schumacher F, Henderson BE, Le Marchand L, Lindstrom S, Kraft P, Hunter DJ, Gapstur S, Chanock SJ, Berndt SI, Albanes D, Andriole G, Schleutker J, Weischer M, Canzian F, Riboli E, Key TJ, Travis RC, Campa D, Ingles SA, John EM, Hayes RB, Pharoah PD, Pashayan N, Khaw KT, Stanford JL, Ostrander EA, Signorello LB, Thibodeau SN, Schaid D, Maier C, Vogel W, Kibel AS, Cybulski C, Lubinski J, Cannon-Albright L, Brenner H, Park JY, Kaneva R, Batra J, Spurdle AB, Clements JA, Teixeira MR, Dicks E, Lee A, Dunning AM, Baynes C, Conroy D, Maranian MJ, Ahmed S, Govindasami K, Guy M, Wilkinson RA, Sawyer EJ, Morgan A, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As NJ, Woodhouse CJ, Thompson A, Dudderidge T, Ogden C, Cooper CS, Lophatananon A, Cox A, Southey MC, Hopper JL, English DR, Aly M, Adolfsson J, Xu J, Zheng SL, Yeager M, Kaaks R, Diver WR, Gaudet MM, Stern MC, Corral R, Joshi AD, Shahabi A, Wahlfors T, Tammela TL, Auvinen A, Virtamo J, Klarskov P, Nordestgaard BG, Røder MA, Nielsen SF, Bojesen SE, Siddiq A, Fitzgerald LM, Kolb S, Kwon EM, Karyadi DM, Blot WJ, Zheng W, Cai Q, McDonnell SK, Rinckleb AE, Drake B, Colditz G, Wokolorczyk D, Stephenson RA, Teerlink C, Muller H, Rothenbacher D, Sellers TA, Lin HY, Slavov C, Mitev V, Lose F, Srinivasan S, Maia S, Paulo P, Lange E, Cooney KA, Antoniou AC, Vincent D, Bacot F, Tessier DC, Kote-Jarai Z, Easton DF

COGS–Cancer Research UK GWAS–ELLIPSE (part of GAME-ON) Initiative · Australian Prostate Cancer Bioresource · UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology · UK ProtecT (Prostate testing for cancer and Treatment) Study Collaborators · PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium

Nature genetics · 2013 · PMID 23535732

Questions about rs2273669

What is rs2273669?

rs2273669 is a single position in the genome, in or near the LACE1 gene. Published research associates it with prostate cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2273669 linked to?

On MyGeneLog this position is linked to Prostate Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs2273669 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2273669 come from?

GWAS Catalog, Nat Genet 2013, PMID:23535732. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Prostate cancer (rs2273669). MyGeneLog™. https://www.mygenelog.com/variants/rs2273669

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