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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 8,901 European ancestry cases, 64,477 European ancestry controls; replicated in 4,162 European ancestry cases, 13,599 European ancestry controls.
The effect
Each copy of the A allele carried 1.11 times the odds of Squamous cell lung carcinoma (95% confidence interval 1.08-1.149); p = 1 × 10−11.
How common The A allele had a frequency of about 40% in the people studied.
Where it sits Chromosome 8, band 8p21.2 — in the 3′ untranslated region of PTK2B.
What each result means
A/ATwo copies of the version the research linked to Squamous cell lung carcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Squamous cell lung carcinoma. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Squamous cell lung carcinoma. This is the starting point the study compared everyone against.
Nature communications · 2024 · PMID 39366959 · open access
Questions about rs2271920
What is rs2271920?
rs2271920 is a single position in the genome, in or near the PTK2B gene. Published research associates it with squamous cell lung carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2271920 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2271920 come from?
GWAS Catalog, Nature communications 2024, PMID:39366959. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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