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Who was studied 19,840 European ancestry individuals; replicated in Up to 20,623 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.07 s.d. higher (95% confidence interval 0.01-0.13); p = 9 × 10−13.
How common The A allele had a frequency of about 11% in the people studied.
Where it sits Chromosome 16, band 16q22.1 — in an intron of NUTF2.
What each result means
A/ATwo copies of the version the research linked to HDL cholesterol. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to HDL cholesterol. That is a smaller link than two copies.
G/GNo copy of the version the research linked to HDL cholesterol. This is the starting point the study compared everyone against.
rs2271293 is a single position in the genome, in or near the LCAT gene. Published research associates it with hdl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2271293 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
Does having rs2271293 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2271293 come from?
GWAS Catalog, Nat Genet 2008, PMID:19060906. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
3 483217223127Reads by AI crawlersClaude3ChatGPT2Google · Gemini0Perplexity1Meta AI7Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others27Total48Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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