HNF1B · rs2269841
Where this position leads
Condition: C-Reactive Protein Levels
What the study found
Who was studied 418,642 British ancestry individuals.
The effect Each copy of the A allele shifted the measure 0.0211 lower (95% confidence interval 0.016-0.026); p = 2 × 10−19.
How common The A allele had a frequency of about 72% in the people studied.
Where it sits Chromosome 17, band 17q12 — in an intron of HNF1B.
What ClinVar records
Classification
Benign for Maturity-onset diabetes of the young; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2018-06-14.
ClinVar record 676878 NM_000458.4(HNF1B):c.1535-177T>C
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs2269841 is a single position in the genome, in or near the HNF1B gene. Published research associates it with c-reactive protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to C-Reactive Protein Levels. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, European journal of epidemiology 2020, PMID:31900758. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
C-reactive protein levels (rs2269841). MyGeneLog™. https://www.mygenelog.com/variants/rs2269841