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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 14,733 European ancestry individuals; replicated in 1,585 European or unknown ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.171 lower (95% confidence interval 0.15-0.19); p = 3 × 10−50.
How common The T allele had a frequency of about 56% in the people studied.
Where it sits Chromosome 8, band 8q24.12 — in an intron of COLEC10.
What each result means
C/CNo copy of the version the research linked to Osteoprotegerin levels. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Osteoprotegerin levels. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Osteoprotegerin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature immunology · 2023 · PMID 37563310 · open access
Questions about rs2247769
What is rs2247769?
rs2247769 is a single position in the genome, in or near the COLEC10 gene. Published research associates it with osteoprotegerin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2247769 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2247769 come from?
GWAS Catalog, Nature immunology 2023, PMID:37563310. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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