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Who was studied 215,551 European ancestry individuals, 57,332 African American individuals, 24,743 Hispanic individuals; replicated in Up to 319,677 individuals.
The effect
Each copy of the A allele shifted the measure 0.0131 mg dl-1 higher (95% confidence interval 0.0088-0.0174); p = 5 × 10−9.
How common The A allele had a frequency of about 32% in the people studied.
Where it sits Chromosome 15, band 15q22.31 — in an intron of LINC01169.
What each result means
A/ATwo copies of the version the research linked to Triglycerides. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Triglycerides. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Triglycerides. This is the starting point the study compared everyone against.
Nature genetics · 2018 · PMID 30275531 · open access
Questions about rs2245586
What is rs2245586?
rs2245586 is a single position in the genome, in or near the RP11-321F6.1 gene. Published research associates it with triglycerides. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2245586 linked to?
On MyGeneLog this position is linked to High Triglycerides. The research behind each link, and its sources, are set out on that condition page.
Does having rs2245586 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2245586 come from?
GWAS Catalog, Nature genetics 2018, PMID:30275531. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 312Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total3Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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