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Who was studied 2,523 Korean ancestry cases, 76,598 Korean ancestry controls.
The effect
Each copy of the G allele carried 0.79 times the odds of Crohn's disease (95% confidence interval 0.74-0.85); p = 2 × 10−10.
How common The G allele had a frequency of about 38% in the people studied.
Where it sits Chromosome 10, band 10q21.2 — between genes, 34.2 kb from ALDH7A1P4.
What each result means
A/ANo copy of the version the research linked to Crohn's disease. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Crohn's disease. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Journal of Crohn's & colitis · 2024 · PMID 37523193
Questions about rs224135
What is rs224135?
rs224135 is a single position in the genome, in or near the near ALDH7A1P4 gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs224135 linked to?
On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs224135 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs224135 come from?
GWAS Catalog, Journal of Crohn's & colitis 2024, PMID:37523193. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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