TBX2 · rs2240736
Where this position leads
Condition: Blood Pressure
What the study found
Who was studied 295,529 European ancestry individuals, 8,231 Latino individuals, 3,058 African American individuals, 2,029 African British individuals, 7,701 East Asian ancestry individuals, 2,735 South Asian ancestry individuals, 1,979 mixed and unknown ancestry individuals.
The effect Each copy of the C allele shifted the measure 0.286 lower; p = 1 × 10−10.
Where it sits Chromosome 17, band 17q23.2 — in an intron of TBX2-AS1.
What ClinVar records
Classification
Benign for Vertebral anomalies and variable endocrine and T-cell dysfunction; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2021-07-15.
ClinVar record 1334936 NM_005994.4(TBX2):c.1687-22C>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs2240736 is a single position in the genome, in or near the TBX2 gene. Published research associates it with systolic blood pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2017, PMID:27841878. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Systolic blood pressure (rs2240736). MyGeneLog™. https://www.mygenelog.com/variants/rs2240736