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Factor VIII levels

VWF · rs2238109

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 25,897 European ancestry individuals, 4,500 African American individuals, 773 Asian ancestry individuals, 1,440 Hispanic individuals.

The effect Each copy of the A allele shifted the measure 0.026 higher; p = 4 × 10−24.

How common The A allele had a frequency of about 39% in the people studied.

Where it sits Chromosome 12, band 12p13.31 — in an intron of VWF.

What each result means

A/A Two copies of the version the research linked to Factor VIII levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/T One copy of the version the research linked to Factor VIII levels. That is a smaller link than two copies.
T/T No copy of the version the research linked to Factor VIII levels. This is the starting point the study compared everyone against.
Source
Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels
Sabater-Lleal M, Huffman JE, de Vries PS, Marten J, Mastrangelo MA, Song C, Pankratz N, Ward-Caviness CK, Yanek LR, Trompet S, Delgado GE, Guo X
and 64 more — show all
Bartz TM, Martinez-Perez A, Germain M, de Haan HG, Ozel AB, Polasek O, Smith AV, Eicher JD, Reiner AP, Tang W, Davies NM, Stott DJ, Rotter JI, Tofler GH, Boerwinkle E, de Maat MPM, Kleber ME, Welsh P, Brody JA, Chen MH, Vaidya D, Soria JM, Suchon P, van Hylckama Vlieg A, Desch KC, Kolcic I, Joshi PK, Launer LJ, Harris TB, Campbell H, Rudan I, Becker DM, Li JZ, Rivadeneira F, Uitterlinden AG, Hofman A, Franco OH, Cushman M, Psaty BM, Morange PE, McKnight B, Chong MR, Fernandez-Cadenas I, Rosand J, Lindgren A, Gudnason V, Wilson JF, Hayward C, Ginsburg D, Fornage M, Rosendaal FR, Souto JC, Becker LC, Jenny NS, März W, Jukema JW, Dehghan A, Trégouët DA, Morrison AC, Johnson AD, O'Donnell CJ, Strachan DP, Lowenstein CJ, Smith NL
INVENT Consortium; MEGASTROKE Consortium of the International Stroke Genetics Consortium (ISGC)
Circulation · 2019 · PMID 30586737

Questions about rs2238109

What is rs2238109?

rs2238109 is a single position in the genome, in or near the VWF gene. Published research associates it with factor viii levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2238109 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2238109 come from?

GWAS Catalog, Circulation 2018, PMID:30586737. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Factor VIII levels (rs2238109). MyGeneLog™. https://www.mygenelog.com/variants/rs2238109

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