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Hemojuvelin levels

TMEM8B · rs2236293

What the study found

Who was studied 997 European ancestry individuals; replicated in 338 Greater Middle Eastern (Middle Eastern, North African or Persian), South Asian ancestry, Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.328 lower (95% confidence interval 0.24-0.41); p = 5 × 10−14.

Where it sits Chromosome 9, band 9p13.3 — a missense change in TMEM8B.

What each result means

A/A Two copies of the version the research linked to Hemojuvelin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Hemojuvelin levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Hemojuvelin levels. This is the starting point the study compared everyone against.
Source

Questions about rs2236293

What is rs2236293?

rs2236293 is a single position in the genome, in or near the TMEM8B gene. Published research associates it with hemojuvelin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2236293 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2236293 come from?

GWAS Catalog, Nature communications 2017, PMID:28240269. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Hemojuvelin levels (rs2236293). MyGeneLog™. https://www.mygenelog.com/variants/rs2236293

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