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Who was studied 77,690 European ancestry cases, 1,167,040 European ancestry controls, 67,864 Japanese ancestry cases, 1,026,594 Japanese ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.0362 higher (95% confidence interval 0.025-0.048); p = 3 × 10−10.
How common The T allele had a frequency of about 48% in the people studied.
Where it sits Chromosome 4, band 4q24 — between genes, 2.3 kb from UBE2D3.
What each result means
A/ANo copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2023 · PMID 36653681 · open access
Questions about rs223449
What is rs223449?
rs223449 is a single position in the genome, in or near the near UBE2D3 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs223449 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs223449 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs223449 come from?
GWAS Catalog, Nature genetics 2023, PMID:36653681. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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