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Asthma

TNFRSF8 · rs2230624

Where this position leads

Condition: Asthma

rs2230624 Condition: Asthma Asthma Condition rs2230624 rs2230624 TNFRSF8

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Asthma — no copies of the reported risk allele. (GWAS Catalog, Nat Commun 2020, PMID:31959851)
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Asthma. (GWAS Catalog, Nat Commun 2020, PMID:31959851)
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Asthma compared to the general population. (GWAS Catalog, Nat Commun 2020, PMID:31959851)
Source
Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis
Olafsdottir TA, Theodors F, Bjarnadottir K, Bjornsdottir US, Agustsdottir AB, Stefansson OA, Ivarsdottir EV, Sigurdsson JK, Benonisdottir S, Eyjolfsson GI, Gislason D, Gislason T
and 23 more — show all
Guðmundsdóttir S, Gylfason A, Halldorsson BV, Halldorsson GH, Juliusdottir T, Kristinsdottir AM, Ludviksdottir D, Ludviksson BR, Masson G, Norland K, Onundarson PT, Olafsson I, Sigurdardottir O, Stefansdottir L, Sveinbjornsson G, Tragante V, Gudbjartsson DF, Thorleifsson G, Sulem P, Thorsteinsdottir U, Norddahl GL, Jonsdottir I, Stefansson K
Nature communications · 2020 · PMID 31959851 · open access

Questions about rs2230624

What is rs2230624?

rs2230624 is a single position in the genome, in or near the TNFRSF8 gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2230624 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs2230624 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2230624 come from?

GWAS Catalog, Nat Commun 2020, PMID:31959851. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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