NT5E · rs2229523
Where this position leads
Condition: Colorectal Cancer
What the study found
Who was studied 869 European ancestry individuals.
The effect Each copy of the A allele shifted the measure 0.52 higher (95% confidence interval 0.4-0.64); p = 2 × 10−15.
How common The A allele had a frequency of about 34% in the people studied.
Where it sits Chromosome 6, band 6q14.3 — a missense change in NT5E.
What ClinVar records
Classification
Benign for Hereditary arterial and articular multiple calcification syndrome; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 5 submitters), last evaluated 2024-11-27.
ClinVar record 1175159 NM_002526.4(NT5E):c.1126A>G (p.Thr376Ala)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs2229523 is a single position in the genome, in or near the NT5E gene. Published research associates it with cd73 levels in metastatic colorectal cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Colorectal Cancer. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, BMC genomics 2024, PMID:38745123. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
CD73 levels in metastatic colorectal cancer (rs2229523). MyGeneLog™. https://www.mygenelog.com/variants/rs2229523