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White blood cell count

MED24 · rs2227336

Where this position leads

What the study found

Who was studied up to 11,809 Hispanic/Latino American individuals; replicated in up to 7,200 Hispanic/Latino American individuals.

The effect Each copy of the T allele shifted the measure 0.0262 lower (95% confidence interval 0.018-0.034); p = 9 × 10⁻¹¹.

How common The T allele had a frequency of about 66% in the people studied.

Where it sits Chromosome 17, band 17q21.1 — between genes, 0.5 kb from MED24.

What each result means

G/G Published research associates this genotype with typical/baseline likelihood of White blood cell count — no copies of the reported risk allele.

G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with White blood cell count.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of White blood cell count compared to the general population.

Source

Genome-wide association of white blood cell counts in Hispanic/Latino Americans: the Hispanic Community Health Study/Study of Latinos

Jain D, Hodonsky CJ, Schick UM, Morrison JV, Minnerath S, Brown L, Schurmann C, Liu Y, Auer PL, Laurie CA, Taylor KD, Browning BL

and 9 more — show all

Papanicolaou G, Browning SR, Loos RJF, North KE, Thyagarajan B, Laurie CC, Thornton TA, Sofer T, Reiner AP

Human molecular genetics · 2017 · PMID 28158719

Questions about rs2227336

What is rs2227336?

rs2227336 is a single position in the genome, in or near the MED24 gene. Published research associates it with white blood cell count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2227336 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs2227336 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2227336 come from?

GWAS Catalog, Hum Mol Genet 2017, PMID:28158719. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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