DENND1B · rs2224873
Where this position leads
What the study found
Who was studied 17,054 endometriosis cases, 170,756 European ancestry depression cases, 191,858 controls, 329,443 European ancestry controls.
The effect Each copy of the A allele shifted the measure 0.03 lower (95% confidence interval 0.02-0.04); p = 1 × 10−9.
Where it sits Chromosome 1, band 1q31.3 — in an intron of DENND1B.
rs2224873 is a single position in the genome, in or near the DENND1B gene. Published research associates it with endometriosis or depression (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Endometriosis and Depression: Shared Genetics. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Hum Genet 2020, PMID:32959083. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Endometriosis or depression (pleiotropy) (rs2224873). MyGeneLog™. https://www.mygenelog.com/variants/rs2224873