HTRA1-AS1 · rs2223089
Where this position leads
Condition: Migraine
What the study found
Who was studied 85,726 European ancestry cases, 803,292 European ancestry controls.
The effect The reported allele is C; the catalogue records no effect size ; p = 1 × 10−12.
How common The C allele had a frequency of about 9% in the people studied.
Where it sits Chromosome 10, band 10q26.13 — in a non-coding transcript of HTRA1-AS1.
rs2223089 is a single position in the genome, in or near the HTRA1-AS1 gene. Published research associates it with migraine. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Migraine. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Communications biology 2021, PMID:34294844. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Migraine (rs2223089). MyGeneLog™. https://www.mygenelog.com/variants/rs2223089