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Serum total bilirubin levels

UGT1A4 · rs2221198

What the study found

Who was studied 9,664 Korean ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.149 mg/dL lower; p = 3 × 10−150.

How common The A allele had a frequency of about 28% in the people studied.

Where it sits Chromosome 2, band 2q37.1 — in an intron of UGT1A4.

What each result means

A/A Two copies of the version the research linked to Serum total bilirubin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Serum total bilirubin levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Serum total bilirubin levels. This is the starting point the study compared everyone against.
Source

Questions about rs2221198

What is rs2221198?

rs2221198 is a single position in the genome, in or near the UGT1A4 gene. Published research associates it with serum total bilirubin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2221198 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2221198 come from?

GWAS Catalog, Scientific reports 2022, PMID:35121771. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Serum total bilirubin levels (rs2221198). MyGeneLog™. https://www.mygenelog.com/variants/rs2221198

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