Gene Knowledge Graph
UTC
Sensitive

Endometriosis or endometrial cancer (pleiotropy)

OR9Q1 · rs2218868

Where this position leads

Condition: Endometrial Cancer

rs2218868 Condition: Endometrial Cancer Endometrial Cancer Condition rs2218868 rs2218868 OR9Q1

What the study found

Who was studied 3,194 endometriosis cases, 5,330 non-endometriosis controls, 2,057 endometrial cancer cases, 3,866 non-endometrial cancer controls.

The effect Each copy of the T allele carried 1.15 times the odds of Endometriosis or endometrial cancer (pleiotropy) (95% confidence interval 1.09-1.21); p = 4 × 10−8.

Where it sits Chromosome 11, band 11q12.1 — in an intron of OR9Q1.

What each result means

C/C No copy of the version the research linked to Endometriosis or endometrial cancer (pleiotropy). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Endometriosis or endometrial cancer (pleiotropy). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Endometriosis or endometrial cancer (pleiotropy). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses
Painter JN, O'Mara TA, Morris AP, Cheng THT, Gorman M, Martin L, Hodson S, Jones A, Martin NG, Gordon S, Henders AK, Attia J
and 65 more — show all
McEvoy M, Holliday EG, Scott RJ, Webb PM, Fasching PA, Beckmann MW, Ekici AB, Hein A, Rübner M, Hall P, Czene K, Dörk T, Dürst M, Hillemanns P, Runnebaum I, Lambrechts D, Lambrechts D, Amant F, Annibali D, Depreeuw J, Vanderstichele A, Goode EL, Cunningham JM, Dowdy SC, Winham SJ, Trovik J, Hoivik E, Werner HMJ, Krakstad C, Ashton K, Otton G, Proietto T, Tham E, Mints M, Ahmed S, Healey CS, Shah M, Pharoah PDP, Dunning AM, Dennis J, Bolla MK, Michailidou K, Wang Q, Tyrer JP, Hopper JL, Peto J, Swerdlow AJ, Burwinkel B, Brenner H, Meindl A, Brauch H, Lindblom A, Chang-Claude J, Couch FJ, Giles GG, Kristensen VN, Cox A, Zondervan KT, Nyholt DR, MacGregor S, Montgomery GW, Tomlinson I, Easton DF, Thompson DJ, Spurdle AB
Cancer medicine · 2018 · PMID 29608257 · open access

Questions about rs2218868

What is rs2218868?

rs2218868 is a single position in the genome, in or near the OR9Q1 gene. Published research associates it with endometriosis or endometrial cancer (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2218868 linked to?

On MyGeneLog this position is linked to Endometrial Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs2218868 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2218868 come from?

GWAS Catalog, Cancer Med 2018, PMID:29608257. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Endometriosis or endometrial cancer (pleiotropy) (rs2218868). MyGeneLog™. https://www.mygenelog.com/variants/rs2218868

← See all variants