Sensitive

Osteoarthritis of the hip or knee

near NEK4P1 · rs2205325

Where this position leads

What the study found

Who was studied 201,533 European ancestry cases, 901,637 European ancestry controls, 5,506 East Asian ancestry cases, 126,769 East Asian ancestry controls, 4,149 African or African American cases, 21,448 African or African American controls, 1,087 South Asian ancestry cases, 18,871 South Asian ancestry controls, 842 Hispanic cases, 3,489 Hispanic controls, 722 Admixed ancestry cases, 8,268 Admixed ancestry controls.

The effect Each copy of the C allele carried 1.04 times the odds of Osteoarthritis of the hip or knee (95% confidence interval 1.0275487981733-1.04542535575618); p = 7 × 10⁻¹⁶.

How common The C allele had a frequency of about 73% in the people studied.

Where it sits Chromosome 21, band 21q21.1 — between genes, 199 kb from NEK4P1.

What each result means

C/C Two copies of the version the research linked to Osteoarthritis of the hip or knee. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/G One copy of the version the research linked to Osteoarthritis of the hip or knee. That is a smaller link than two copies.

G/G No copy of the version the research linked to Osteoarthritis of the hip or knee. This is the starting point the study compared everyone against.

Source

Translational genomics of osteoarthritis in 1,962,069 individuals

Hatzikotoulas K, Southam L, Stefansdottir L, Boer CG, McDonald ML, Pett JP, Park YC, Tuerlings M, Mulders R, Barysenka A, Arruda AL, Tragante V

and 162 more — show all

Rocco A, Bittner N, Chen S, Horn S, Srinivasasainagendra V, To K, Katsoula G, Kreitmaier P, Tenghe AMM, Gilly A, Arbeeva L, Chen LG, de Pins AM, Dochtermann D, Henkel C, Höijer J, Ito S, Lind PA, Lukusa-Sawalena B, Minn AKK, Mola-Caminal M, Narita A, Nguyen C, Reimann E, Silberstein MD, Skogholt AH, Tiwari HK, Yau MS, Yue M, Zhao W, Zhao W, Zhou JJ, Alexiadis G, Banasik K, Brunak S, Campbell A, Cheung JTS, Dowsett J, Faquih T, Faul JD, Fei L, Fenstad AM, Funayama T, Gabrielsen ME, Gocho C, Gromov K, Hansen T, Hudjashov G, Ingvarsson T, Johnson JS, Jonsson H, Kakehi S, Karjalainen J, Kasbohm E, Lemmelä S, Lin K, Liu X, Loef M, Mangino M, McCartney D, Millwood IY, Richman J, Roberts MB, Ryan KA, Samartzis D, Shivakumar M, Skou ST, Sugimoto S, Suzuki K, Takuwa H, Teder-Laving M, Thomas L, Tomizuka K, Turman C, Weiss S, Wu TT, Zengini E, Zhang Y, Ferreira MAR, Babis G, Baras A, Barker T, Carey DJ, Cheah KSE, Chen Z, Cheung JP, Daly M, de Mutsert R, Eaton CB, Erikstrup C, Furnes ON, Golightly YM, Gudbjartsson DF, Hailer NP, Hayward C, Hochberg MC, Homuth G, Huckins LM, Hveem K, Ikegawa S, Ishijima M, Isomura M, Jones M, Kang JH, Kardia SLR, Kloppenburg M, Kraft P, Kumahashi N, Kuwata S, Lee MTM, Lee PH, Lerner R, Li L, Lietman SA, Lotta L, Lupton MK, Mägi R, Martin NG, McAlindon TE, Medland SE, Michaëlsson K, Mitchell BD, Mook-Kanamori DO, Morris AP, Nabika T, Nagami F, Nelson AE, Ostrowski SR, Palotie A, Pedersen OB, Rosendaal FR, Sakurai-Yageta M, Schmidt CO, Sham PC, Singh JA, Smelser DT, Smith JA, Song YQ, Sørensen E, Tamiya G, Tamura Y, Terao C, Thorleifsson G, Troelsen A, Tsezou A, Uchio Y, Uitterlinden AG, Ullum H, Valdes AM, van Heel DA, Walters RG, Weir DR, Wilkinson JM, Winsvold BS, Yamamoto M, Zwart JA, Stefansson K, Meulenbelt I, Teichmann SA, van Meurs JBJ, Styrkarsdottir U, Zeggini E

arcOGEN Consortium · ARGO Consortium · DBDS Genomic Consortium · Estonian Biobank Research Team · FinnGen · Genes & Health Research Team · HUNT All-In Pain · Million Veteran Program · Regeneron Genetics Center

Nature · 2025 · PMID 40205036 · open access

Questions about rs2205325

What is rs2205325?

rs2205325 is a single position in the genome, in or near the near NEK4P1 gene. Published research associates it with osteoarthritis of the hip or knee. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2205325 linked to?

On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs2205325 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2205325 come from?

GWAS Catalog, Nature 2025, PMID:40205036. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Osteoarthritis of the hip or knee (rs2205325). MyGeneLog™. https://www.mygenelog.com/variants/rs2205325

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