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Sex hormone-binding globulin levels

LINC02775 · rs2196943

What the study found

Who was studied 148,248 British ancestry men.

The effect Each copy of the A allele shifted the measure 0.65 nmol/L lower (95% confidence interval 0.49-0.81); p = 4 × 10−15.

How common The A allele had a frequency of about 64% in the people studied.

Where it sits Chromosome 1, band 1q32.3 — in an intron of LINC02775.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Sex hormone-binding globulin levels compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Sex hormone-binding globulin levels.
G/G Published research associates this genotype with typical/baseline likelihood of Sex hormone-binding globulin levels — no copies of the reported risk allele.
Source

Questions about rs2196943

What is rs2196943?

rs2196943 is a single position in the genome, in or near the LINC02775 gene. Published research associates it with sex hormone-binding globulin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2196943 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2196943 come from?

GWAS Catalog, Science advances 2021, PMID:34321204. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Sex hormone-binding globulin levels (rs2196943). MyGeneLog™. https://www.mygenelog.com/variants/rs2196943

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