Who was studied 133,492 European ancestry individuals.
The effect
The reported allele is C; the catalogue records no effect size
; p = 1 × 10−10.
How common The C allele had a frequency of about 58% in the people studied.
Where it sits Chromosome 7, band 7q31.31 — between genes, 121.2 kb from CTTNBP2.
What each result means
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Intraocular pressure compared to the general population.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Intraocular pressure.
T/TPublished research associates this genotype with typical/baseline likelihood of Intraocular pressure — no copies of the reported risk allele.
rs2188836 is a single position in the genome, in or near the CTTNBP2 gene. Published research associates it with intraocular pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2188836 linked to?
On MyGeneLog this position is linked to Intraocular Pressure. The research behind each link, and its sources, are set out on that condition page.
Does having rs2188836 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2188836 come from?
GWAS Catalog, Nature genetics 2020, PMID:31959993. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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