Standard
Disc degeneration (lumbar)
PSMB9 · rs2187689
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Disc degeneration (lumbar) compared to the general population.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Disc degeneration (lumbar).
T/T
Published research associates this genotype with typical/baseline likelihood of Disc degeneration (lumbar) — no copies of the reported risk allele.
Source
Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects
Williams FM,
Bansal AT,
van Meurs JB,
Bell JT,
Meulenbelt I,
Suri P,
Rivadeneira F,
Sambrook PN,
Hofman A,
Bierma-Zeinstra S,
Menni C,
Kloppenburg M
and 5 more — show all
Annals of the rheumatic diseases · 2013 · PMID 22993228 · open access
Questions about rs2187689
What is rs2187689?
rs2187689 is a single position in the genome, in or near the PSMB9 gene. Published research associates it with disc degeneration (lumbar). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2187689 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2187689 come from?
GWAS Catalog, Ann Rheum Dis 2012, PMID:22993228. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants