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Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 137,136 European ancestry cases, 1,085,746 European ancestry controls, 11,560 African or Admixed ancestry cases, 39,474 African or Admixed ancestry controls, 2,064 Native American or Latin American cases, 4,953 Native American or Latin American controls.
The effect
Each copy of the A allele shifted the measure 5.59 z score higher; p = 2 × 10−8.
How common The A allele had a frequency of about 50% in the people studied.
Where it sits Chromosome 1, band 1p31.3 — in an intron of PDE4B.
What each result means
A/ATwo copies of the version the research linked to Post-traumatic stress disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Post-traumatic stress disorder. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Post-traumatic stress disorder. This is the starting point the study compared everyone against.
rs2186120 is a single position in the genome, in or near the PDE4B gene. Published research associates it with post-traumatic stress disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2186120 linked to?
On MyGeneLog this position is linked to Post-Traumatic Stress Disorder (PTSD). The research behind each link, and its sources, are set out on that condition page.
Does having rs2186120 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2186120 come from?
GWAS Catalog, Nature genetics 2024, PMID:38637617. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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