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Dehydroepiandrosterone sulphate levels

CYP2C9 · rs2185570

Where this position leads

Drugs: Acenocoumarol and phenprocoumon, NSAIDs, Phenytoin and fosphenytoin, Siponimod, Statins, Sulfonylureas, Warfarin

rs2185570 Drug: Acenocoumarol and phenprocoumon Acenocoumarol and phenprocoumon Drug Drug: NSAIDs NSAIDs Drug Drug: Phenytoin and fosphenytoin Phenytoin and fosphenytoin Drug Drug: Siponimod Siponimod Drug Drug: Statins Statins Drug Drug: Sulfonylureas Sulfonylureas Drug Drug: Warfarin Warfarin Drug rs2185570 rs2185570 CYP2C9

What the study found

Who was studied 14,846 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.06 umol/L lower (95% confidence interval 0.04-0.08); p = 2 × 10−8.

How common The C allele had a frequency of about 13% in the people studied.

Where it sits Chromosome 10, band 10q23.33 — between genes, 1.4 kb from CYP2C9.

What each result means

C/C Two copies of the version the research linked to Dehydroepiandrosterone sulphate levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Dehydroepiandrosterone sulphate levels. That is a smaller link than two copies.
T/T No copy of the version the research linked to Dehydroepiandrosterone sulphate levels. This is the starting point the study compared everyone against.
Source
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms
Zhai G, Teumer A, Stolk L, Perry JR, Vandenput L, Coviello AD, Koster A, Bell JT, Bhasin S, Eriksson J, Eriksson A, Ernst F
and 34 more — show all
Ferrucci L, Frayling TM, Glass D, Grundberg E, Haring R, Hedman AK, Hofman A, Kiel DP, Kroemer HK, Liu Y, Lunetta KL, Maggio M, Lorentzon M, Mangino M, Melzer D, Miljkovic I, Nica A, Penninx BW, Vasan RS, Rivadeneira F, Small KS, Soranzo N, Uitterlinden AG, Völzke H, Wilson SG, Xi L, Zhuang WV, Harris TB, Murabito JM, Ohlsson C, Murray A, de Jong FH, Spector TD, Wallaschofski H
MuTHER Consortium
PLoS genetics · 2011 · PMID 21533175 · open access

Questions about rs2185570

What is rs2185570?

rs2185570 is a single position in the genome, in or near the CYP2C9 gene. Published research associates it with dehydroepiandrosterone sulphate levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs2185570 affect how medicines work?

CYP2C9 carries pharmacogenomic findings for Acenocoumarol and phenprocoumon, NSAIDs, Phenytoin and fosphenytoin, Siponimod, Statins, Sulfonylureas, Warfarin. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs2185570 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2185570 come from?

GWAS Catalog, PLoS genetics 2011, PMID:21533175. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Dehydroepiandrosterone sulphate levels (rs2185570). MyGeneLog™. https://www.mygenelog.com/variants/rs2185570

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