Gene Knowledge Graph
UTC
Sensitive

Thyroid cancer

near BRMS1L · rs2183451

Where this position leads

Condition: Thyroid Cancer

rs2183451 Condition: Thyroid Cancer Thyroid Cancer Condition rs2183451 rs2183451 near BRMS1L

Strength of the evidence

3 / 4

Its strongest genetic-study result is p = 10−98, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 21,816 African ancestry, admixed American, East Asian ancestry, European ancestry, South Asian ancestry, Greater Middle Eastern cases, 2,895,812 African ancestry, admixed American, East Asian ancestry, European ancestry, South Asian ancestry, Greater Middle Eastern controls.

The effect Each copy of the G allele shifted the measure 0.237 higher (95% confidence interval 0.22-0.26); p = 7 × 10−99.

How common The G allele had a frequency of about 48% in the people studied.

Where it sits Chromosome 14, band 14q13.2 — in an intron of LINC00609.

How common each version is

GT
Korean KRGDB
G 42.1% · T 57.9%
Korean Korea4K
G 39.6% · T 60.4%
Korean Korea1K
G 39.1% · T 60.9%
Japanese ToMMo
G 39.7% · T 60.3%
Vietnamese
G 38.2% · T 61.8%
World gnomAD
G 43.9% · T 56.1%
World 1000 Genomes
G 38.3% · T 61.7%
World TOPMed
G 41.5% · T 58.5%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

G/G Two copies of the version the research linked to Thyroid cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to Thyroid cancer. That is a smaller link than two copies.
T/T No copy of the version the research linked to Thyroid cancer. This is the starting point the study compared everyone against.
Source
Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases
White SL, Brasher MS, Pattee J, Zhou W, Chapman S, Jee YH, Bell CC, Jamil TL, Barrio M, Arehart CH, Evans LM, Hirbo J
and 73 more — show all
Cox NJ, Straub P, Namba S, Bertucci-Richter E, Guare L, Edris A, Morris S, Mulford AJ, Zhang H, Fennessy B, Tobin MD, Chen J, Williams AT, John C, van Heel DA, Mathur R, Finer S, Moksnes MR, Brumpton BM, Åsvold BO, Peculis R, Rovite V, Konrade I, Wang Y, Crooks K, Chavan S, Fisher MJ, Rafaels N, Lin M, Shortt JA, Sanders AR, Whiteman DC, MacGregor S, Medland SE, Thorsteinsdóttir U, Stefánsson K, Karaderi T, Egan KM, Bocklage T, McCrary HC, Riedlinger G, Salhia B, Shriver C, Phan MD, Farlow JL, Edge S, Kaur V, Churchman ML, Rounbehler RJ, Brock PL, Ringel MD, Pividori M, Schweppe R, Raeburn CD, Walters RG, Chen Z, Li L, Matsuda K, Okada Y, Zöllner S, Verma A, Preuss MH, Kenny E, Hendricks AE, Fishbein L, Kraft P, Daly MJ, Neale BM, Martin AR, Cole JB, Haugen BR, Gignoux CR, Pozdeyev N
Penn Medicine BioBank · Virtual Thyroid Biopsy Consortium · Colorado Center for Personalized Medicine · Genes & Health Research Team · BioBank Japan Project · Global Biobank Meta-analysis Initiative
Nature genetics · 2026 · PMID 41644669 · open access

Questions about rs2183451

What is rs2183451?

rs2183451 is a single position in the genome, in or near the near BRMS1L gene. Published research associates it with thyroid cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2183451 linked to?

On MyGeneLog this position is linked to Thyroid Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs2183451 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2183451 come from?

GWAS Catalog, GWAS Catalog n.d., PMID:41644669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Thyroid cancer (rs2183451). MyGeneLog™. https://www.mygenelog.com/variants/rs2183451

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