Standard
End-stage coagulation
F7/F10 · rs2181540
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of End-stage coagulation — no copies of the reported risk allele. (GWAS Catalog, Ann Neurol 2013, PMID:23381943)
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with End-stage coagulation. (GWAS Catalog, Ann Neurol 2013, PMID:23381943)
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of End-stage coagulation compared to the general population. (GWAS Catalog, Ann Neurol 2013, PMID:23381943)
Source
Ischemic stroke is associated with the ABO locus: the EuroCLOT study
Williams FM,
Carter AM,
Hysi PG,
Surdulescu G,
Hodgkiss D,
Soranzo N,
Traylor M,
Bevan S,
Dichgans M,
Rothwell PM,
Sudlow C,
Farrall M
and 46 more — show all
Silander K,
Kaunisto M,
Wagner P,
Saarela O,
Kuulasmaa K,
Virtamo J,
Salomaa V,
Amouyel P,
Arveiler D,
Ferrieres J,
Wiklund PG,
Ikram MA,
Hofman A,
Boncoraglio GB,
Parati EA,
Helgadottir A,
Gretarsdottir S,
Thorsteinsdottir U,
Thorleifsson G,
Stefansson K,
Seshadri S,
DeStefano A,
Gschwendtner A,
Psaty B,
Longstreth W,
Mitchell BD,
Cheng YC,
Clarke R,
Ferrario M,
Bis JC,
Levi C,
Attia J,
Holliday EG,
Scott RJ,
Fornage M,
Sharma P,
Furie KL,
Rosand J,
Nalls M,
Meschia J,
Mosely TH,
Evans A,
Palotie A,
Markus HS,
Grant PJ,
Spector TD
Annals of neurology · 2013 · PMID 23381943 · open access
Questions about rs2181540
What is rs2181540?
rs2181540 is a single position in the genome, in or near the F7/F10 gene. Published research associates it with end-stage coagulation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2181540 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2181540 come from?
GWAS Catalog, Ann Neurol 2013, PMID:23381943. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants