Standard

End-stage coagulation

F7/F10 · rs2181540

Where this position leads

Condition: Fibrinogen and Blood Clotting

rs2181540 Condition: Fibrinogen and Blood Clotting Fibrinogen and Blood Clotting Condition rs2181540 rs2181540 F7/F10

What the study found

Who was studied 2,100 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.834 higher (95% confidence interval 0.72-0.95); p = 1 × 10−46.

How common The T allele had a frequency of about 88% in the people studied.

Where it sits Chromosome 13, band 13q34 — in the 3′ untranslated region of MCF2L.

What each result means

C/C No copy of the version the research linked to End-stage coagulation. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to End-stage coagulation. That is a smaller link than two copies.
T/T Two copies of the version the research linked to End-stage coagulation. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs2181540

What is rs2181540?

rs2181540 is a single position in the genome, in or near the F7/F10 gene. Published research associates it with end-stage coagulation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2181540 linked to?

On MyGeneLog this position is linked to Fibrinogen and Blood Clotting. The research behind each link, and its sources, are set out on that condition page.

Does having rs2181540 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2181540 come from?

GWAS Catalog, Ann Neurol 2013, PMID:23381943. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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End-stage coagulation (rs2181540). MyGeneLog™. https://www.mygenelog.com/variants/rs2181540

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