Standard

Axial length

near BMP4 · rs2181346

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 16,523 European ancestry individuals, 1,209 Hispanic or Latin American individuals, 1,209 East Asian ancestry individuals, 479 African American or Afro-Caribbean individuals.

The effect Each copy of the T allele shifted the measure 0.0808 higher; p = 2 × 10⁻⁸.

Where it sits Chromosome 14, band 14q22.2 — between genes, 93.7 kb from ATP5F1CP1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Axial length — no copies of the reported risk allele.

A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Axial length.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Axial length compared to the general population.

Source

A multiethnic genome-wide analysis of 19,420 individuals identifies novel loci associated with axial length and shared genetic influences with refractive error and myopia

Jiang C, Melles RB, Yin J, Fan Q, Guo X, Cheng CY, He M, Mackey DA, Guggenheim JA, Klaver C, Nair KS, Jorgenson E

and 1 more — show all

Choquet H

Consortium for Refractive Error and Myopia (CREAM)

Frontiers in genetics · 2023 · PMID 37351342 · open access

Questions about rs2181346

What is rs2181346?

rs2181346 is a single position in the genome, in or near the near BMP4 gene. Published research associates it with axial length. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2181346 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2181346 come from?

GWAS Catalog, Frontiers in genetics 2023, PMID:37351342. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Axial length (rs2181346). MyGeneLog™. https://www.mygenelog.com/variants/rs2181346

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