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Heart failure

SYNPO2L · rs2177843

Where this position leads

Condition: Heart Failure

rs2177843 Condition: Heart Failure Heart Failure Condition rs2177843 rs2177843 SYNPO2L

What the study found

Who was studied 168,363 European ancestry cases, 1,725,558 European ancestry controls, 21,202 African ancestry cases, 121,670 African ancestry controls, 12,665 East Asian ancestry cases, 245,263 East Asian ancestry controls, 5,116 Hispanic or Latin American cases, 58,719 Hispanic or Latin American controls.

The effect Each copy of the T allele shifted the measure 0.0515 lower (95% confidence interval 0.042-0.061); p = 1 × 10−26.

How common The T allele had a frequency of about 17% in the people studied.

Where it sits Chromosome 10, band 10q22.2 — in an intron of SYNPO2L.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Heart failure — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Heart failure.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Heart failure compared to the general population.
Source
Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum
Lee DSM, Cardone KM, Zhang DY, Tsao NL, Abramowitz S, Sharma P, DePaolo JS, Conery M, Aragam KG, Biddinger K, Dikilitas O, Hoffman-Andrews L
and 23 more — show all
Judy RL, Khan A, Kullo IJ, Puckelwartz MJ, Reza N, Satterfield BA, Singhal P, Arany Z, Cappola TP, Carruth ED, Day SM, Do R, Haggerty CM, Joseph J, McNally EM, Nadkarni G, Owens AT, Rader DJ, Ritchie MD, Sun YV, Voight BF, Levin MG, Damrauer SM
Penn Medicine Biobank
Nature genetics · 2025 · PMID 40195560

Questions about rs2177843

What is rs2177843?

rs2177843 is a single position in the genome, in or near the SYNPO2L gene. Published research associates it with heart failure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2177843 linked to?

On MyGeneLog this position is linked to Heart Failure. The research behind each link, and its sources, are set out on that condition page.

Does having rs2177843 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2177843 come from?

GWAS Catalog, Nature genetics 2025, PMID:40195560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Heart failure (rs2177843). MyGeneLog™. https://www.mygenelog.com/variants/rs2177843

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