Sensitive

Alzheimer's disease or related dementias

near NME8 · rs2167266

Where this position leads

Condition: Alzheimer's Disease

rs2167266 Condition: Alzheimer's Disease Alzheimer's Disease Condition rs2167266 rs2167266 near NME8

What the study found

Who was studied 75,638 European ancestry cases, 1,043,805 European ancestry controls.

The effect Each copy of the C allele carried 0.95 times the odds of Alzheimer's disease or related dementias (95% confidence interval 0.94-0.96); p = 3 × 10−13.

How common The C allele had a frequency of about 35% in the people studied.

Where it sits Chromosome 7, band 7p14.1 — between genes, 5.7 kb from NME8.

What each result means

C/C Two copies of the version the research linked to Alzheimer's disease or related dementias. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Alzheimer's disease or related dementias. That is a smaller link than two copies.
T/T No copy of the version the research linked to Alzheimer's disease or related dementias. This is the starting point the study compared everyone against.
Source

Questions about rs2167266

What is rs2167266?

rs2167266 is a single position in the genome, in or near the near NME8 gene. Published research associates it with alzheimer's disease or related dementias. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2167266 linked to?

On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs2167266 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2167266 come from?

GWAS Catalog, Nature genetics 2026, PMID:42237039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Alzheimer's disease or related dementias (rs2167266). MyGeneLog™. https://www.mygenelog.com/variants/rs2167266

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