4 34214223119Reads by AI crawlersClaude0ChatGPT2Google · Gemini0Perplexity1Meta AI4Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others19Total34Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 21,768 European ancestry individuals, 2,131 Erasmus Rucphen (founder/genetic isolate) individuals; replicated in 8,168 Asian ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.013 lower (95% confidence interval 0.011-0.015); p = 4 × 10−35.
Where it sits Chromosome 9, band 9p21.3 — in an intron of CDKN2B-AS1.
What each result means
C/CTwo copies of the version the research linked to Vertical cup-disc ratio. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Vertical cup-disc ratio. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Vertical cup-disc ratio. This is the starting point the study compared everyone against.
rs2157719 is a single position in the genome, in or near the CDKN2B-AS1 gene. Published research associates it with vertical cup-disc ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2157719 linked to?
On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs2157719 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2157719 come from?
GWAS Catalog, Hum Mol Genet 2017, PMID:28073927. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
4 34214223119Reads by AI crawlersClaude0ChatGPT2Google · Gemini0Perplexity1Meta AI4Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others19Total34Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Vertical cup-disc ratio (rs2157719). MyGeneLog™. https://www.mygenelog.com/variants/rs2157719