1 22126229Reads by AI crawlersClaude1ChatGPT0Google · Gemini2Perplexity0Meta AI6Microsoft · Copilot0Amazon2Apple2Others9Total22Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 168,105 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0193 higher (95% confidence interval 0.013-0.026); p = 3 × 10−9.
How common The T allele had a frequency of about 24% in the people studied.
Where it sits Chromosome 9, band 9q33.1 — between genes, 14.6 kb from TLR4.
What each result means
G/GPublished research associates this genotype with typical/baseline likelihood of Neuroticism (MTAG) — no copies of the reported risk allele.
G/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Neuroticism (MTAG).
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Neuroticism (MTAG) compared to the general population.
Nature genetics · 2018 · PMID 29292387 · open access
Questions about rs2149351
What is rs2149351?
rs2149351 is a single position in the genome, in or near the near TLR4 gene. Published research associates it with neuroticism (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2149351 linked to?
On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.
Does having rs2149351 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2149351 come from?
GWAS Catalog, Nat Genet 2018, PMID:29292387. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 22126229Reads by AI crawlersClaude1ChatGPT0Google · Gemini2Perplexity0Meta AI6Microsoft · Copilot0Amazon2Apple2Others9Total22Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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