Standard

Vertex-wise sulcal depth

ISCA1 · rs2147064

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 33,748 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 9.24 z score higher; p = 2 × 10⁻²⁰.

How common The C allele had a frequency of about 37% in the people studied.

Where it sits Chromosome 9, band 9q21.33 — in an intron of ISCA1.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Vertex-wise sulcal depth compared to the general population.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Vertex-wise sulcal depth.

T/T Published research associates this genotype with typical/baseline likelihood of Vertex-wise sulcal depth — no copies of the reported risk allele.

Source

The genetic architecture of human cortical folding

van der Meer D, Kaufmann T, Shadrin AA, Makowski C, Frei O, Roelfs D, Monereo-Sánchez J, Linden DEJ, Rokicki J, Alnæs D, de Leeuw C, Thompson WK

and 5 more — show all

Loughnan R, Fan CC, Westlye LT, Andreassen OA, Dale AM

Science advances · 2021 · PMID 34910505 · open access

Questions about rs2147064

What is rs2147064?

rs2147064 is a single position in the genome, in or near the ISCA1 gene. Published research associates it with vertex-wise sulcal depth. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2147064 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2147064 come from?

GWAS Catalog, Science advances 2021, PMID:34910505. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Vertex-wise sulcal depth (rs2147064). MyGeneLog™. https://www.mygenelog.com/variants/rs2147064

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