0 8323Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI3Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others3Total8Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 129,080 European ancestry cases, 473,524 European ancestry controls; replicated in 462,753 cases, 1,127,474 controls.
The effect
Each copy of the T allele shifted the measure 0.035 lower; p = 2 × 10−13.
How common The T allele had a frequency of about 51% in the people studied.
Where it sits Chromosome 6, band 6p22.2 — between genes, 3.9 kb from BTN1A1.
What each result means
A/ANo copy of the version the research linked to Gastroesophageal reflux disease. This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Gastroesophageal reflux disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Gastroesophageal reflux disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs2145318 is a single position in the genome, in or near the HCG11 gene. Published research associates it with gastroesophageal reflux disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2145318 linked to?
On MyGeneLog this position is linked to Gastroesophageal Reflux Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs2145318 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2145318 come from?
GWAS Catalog, Gut 2022, PMID:34187846. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 8323Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI3Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others3Total8Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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