Gene Knowledge Graph UTC
Sensitive

Schizophrenia

SAMD13 · rs2143757

Where this position leads

Condition: Schizophrenia

rs2143757 Condition: Schizophrenia Schizophrenia Condition rs2143757 rs2143757 SAMD13

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Schizophrenia — no copies of the reported risk allele. (GWAS Catalog, Schizophr Bull 2020, PMID:33169155)
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Schizophrenia. (GWAS Catalog, Schizophr Bull 2020, PMID:33169155)
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Schizophrenia compared to the general population. (GWAS Catalog, Schizophr Bull 2020, PMID:33169155)
Source
Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US Veterans
Bigdeli TB, Fanous AH, Li Y, Rajeevan N, Sayward F, Genovese G, Gupta R, Radhakrishnan K, Malhotra AK, Sun N, Lu Q, Hu Y
and 33 more — show all
Li B, Chen Q, Mane S, Miller P, Cheung KH, Gur RE, Greenwood TA, Braff DL, Achtyes ED, Buckley PF, Escamilla MA, Lehrer D, Malaspina DP, McCarroll SA, Rapaport MH, Vawter MP, Pato MT, Pato CN, Zhao H, Kosten TR, Brophy M, Pyarajan S, Shi Y, O'Leary TJ, Gleason T, Przygodzki R, Muralidhar S, Gaziano JM, Huang GD, Concato J, Siever LJ, Aslan M, Harvey PD
Consortium on the Genetics of Schizophrenia (COGS) · Genomic Psychiatry Cohort (GPC) Investigators · Million Veteran Program (MVP)
Schizophrenia bulletin · 2021 · PMID 33169155

Questions about rs2143757

What is rs2143757?

rs2143757 is a single position in the genome, in or near the SAMD13 gene. Published research associates it with schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2143757 linked to?

On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.

Does having rs2143757 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2143757 come from?

GWAS Catalog, Schizophr Bull 2020, PMID:33169155. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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