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Body mass index

near RPSAP1 · rs2143624

Where this position leads

Condition: Childhood Body Mass Index

rs2143624 Condition: Childhood Body Mass Index Childhood Body Mass Index Condition rs2143624 rs2143624 near RPSAP1

What the study found

Who was studied 1,122,049 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0097 lower (95% confidence interval 0.0068-0.0126); p = 2 × 10−10.

Where it sits Chromosome 20, band 20q13.13 — between genes, 33.5 kb from RPSAP1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Body mass index — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Body mass index.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Body mass index compared to the general population.
Source
Genomics and phenomics of body mass index reveals a complex disease network
Huang J, Huffman JE, Huang Y, Do Valle Í, Assimes TL, Raghavan S, Voight BF, Liu C, Barabási AL, Huang RDL, Hui Q, Nguyen XT
and 26 more — show all
Ho YL, Djousse L, Lynch JA, Vujkovic M, Tcheandjieu C, Tang H, Damrauer SM, Reaven PD, Miller D, Phillips LS, Ng MCY, Graff M, Haiman CA, Loos RJF, North KE, Yengo L, Smith GD, Saleheen D, Gaziano JM, Rader DJ, Tsao PS, Cho K, Chang KM, Wilson PWF, Sun YV, O'Donnell CJ
VA Million Veteran Program
Nature communications · 2022 · PMID 36581621 · open access

Questions about rs2143624

What is rs2143624?

rs2143624 is a single position in the genome, in or near the near RPSAP1 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2143624 linked to?

On MyGeneLog this position is linked to Childhood Body Mass Index. The research behind each link, and its sources, are set out on that condition page.

Does having rs2143624 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2143624 come from?

GWAS Catalog, Nature communications 2022, PMID:36581621. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body mass index (rs2143624). MyGeneLog™. https://www.mygenelog.com/variants/rs2143624

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