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Who was studied 56,355 European ancestry cases, 398,413 European ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.09 higher (95% confidence interval 0.063-0.117); p = 3 × 10−10.
How common The T allele had a frequency of about 95% in the people studied.
Where it sits Chromosome 6, band 6p21.2 — a missense change in MTCH1.
What each result means
C/CNo copy of the version the research linked to Diverticular disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Diverticular disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Diverticular disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Cell genomics · 2023 · PMID 37492107 · open access
Questions about rs2140937
What is rs2140937?
rs2140937 is a single position in the genome, in or near the MTCH1 gene. Published research associates it with diverticular disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2140937 linked to?
On MyGeneLog this position is linked to Diverticular Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs2140937 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2140937 come from?
GWAS Catalog, Cell genomics 2023, PMID:37492107. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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