Standard
Drinks per week
near TINAG · rs2136135
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 2,428,851 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.006 lower (95% confidence interval 0.0041-0.0079); p = 2 × 10−10.
How common The G allele had a frequency of about 64% in the people studied.
Where it sits Chromosome 6, band 6p12.1 — between genes, 17.1 kb from TINAG.
What each result means
A/A
Published research associates this genotype with typical/baseline likelihood of Drinks per week — no copies of the reported risk allele.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Drinks per week.
G/G
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Drinks per week compared to the general population.
Source
Genetic diversity fuels gene discovery for tobacco and alcohol use
Saunders GRB,
Wang X,
Chen F,
Jang SK,
Liu M,
Wang C,
Gao S,
Jiang Y,
Khunsriraksakul C,
Otto JM,
Addison C,
Akiyama M
and 205 more — show all
Albert CM,
Aliev F,
Alonso A,
Arnett DK,
Ashley-Koch AE,
Ashrani AA,
Barnes KC,
Barr RG,
Bartz TM,
Becker DM,
Bielak LF,
Benjamin EJ,
Bis JC,
Bjornsdottir G,
Blangero J,
Bleecker ER,
Boardman JD,
Boerwinkle E,
Boomsma DI,
Boorgula MP,
Bowden DW,
Brody JA,
Cade BE,
Chasman DI,
Chavan S,
Chen YI,
Chen Z,
Cheng I,
Cho MH,
Choquet H,
Cole JW,
Cornelis MC,
Cucca F,
Curran JE,
de Andrade M,
Dick DM,
Docherty AR,
Duggirala R,
Eaton CB,
Ehringer MA,
Esko T,
Faul JD,
Fernandes Silva L,
Fiorillo E,
Fornage M,
Freedman BI,
Gabrielsen ME,
Garrett ME,
Gharib SA,
Gieger C,
Gillespie N,
Glahn DC,
Gordon SD,
Gu CC,
Gu D,
Gudbjartsson DF,
Guo X,
Haessler J,
Hall ME,
Haller T,
Harris KM,
He J,
Herd P,
Hewitt JK,
Hickie I,
Hidalgo B,
Hokanson JE,
Hopfer C,
Hottenga J,
Hou L,
Huang H,
Hung YJ,
Hunter DJ,
Hveem K,
Hwang SJ,
Hwu CM,
Iacono W,
Irvin MR,
Jee YH,
Johnson EO,
Joo YY,
Jorgenson E,
Justice AE,
Kamatani Y,
Kaplan RC,
Kaprio J,
Kardia SLR,
Keller MC,
Kelly TN,
Kooperberg C,
Korhonen T,
Kraft P,
Krauter K,
Kuusisto J,
Laakso M,
Lasky-Su J,
Lee WJ,
Lee JJ,
Levy D,
Li L,
Li K,
Li Y,
Lin K,
Lind PA,
Liu C,
Lloyd-Jones DM,
Lutz SM,
Ma J,
Mägi R,
Manichaikul A,
Martin NG,
Mathur R,
Matoba N,
McArdle PF,
McGue M,
McQueen MB,
Medland SE,
Metspalu A,
Meyers DA,
Millwood IY,
Mitchell BD,
Mohlke KL,
Moll M,
Montasser ME,
Morrison AC,
Mulas A,
Nielsen JB,
North KE,
Oelsner EC,
Okada Y,
Orrù V,
Palmer ND,
Palviainen T,
Pandit A,
Park SL,
Peters U,
Peters A,
Peyser PA,
Polderman TJC,
Rafaels N,
Redline S,
Reed RM,
Reiner AP,
Rice JP,
Rich SS,
Richmond NE,
Roan C,
Rotter JI,
Rueschman MN,
Runarsdottir V,
Saccone NL,
Schwartz DA,
Shadyab AH,
Shi J,
Shringarpure SS,
Sicinski K,
Skogholt AH,
Smith JA,
Smith NL,
Sotoodehnia N,
Stallings MC,
Stefansson H,
Stefansson K,
Stitzel JA,
Sun X,
Syed M,
Tal-Singer R,
Taylor AE,
Taylor KD,
Telen MJ,
Thai KK,
Tiwari H,
Turman C,
Tyrfingsson T,
Wall TL,
Walters RG,
Weir DR,
Weiss ST,
White WB,
Whitfield JB,
Wiggins KL,
Willemsen G,
Willer CJ,
Winsvold BS,
Xu H,
Yanek LR,
Yin J,
Young KL,
Young KA,
Yu B,
Zhao W,
Zhou W,
Zöllner S,
Zuccolo L,
Batini C,
Bergen AW,
Bierut LJ,
David SP,
Gagliano Taliun SA,
Hancock DB,
Jiang B,
Munafò MR,
Thorgeirsson TE,
Liu DJ,
Vrieze S
Nature · 2022 · PMID 36477530 · open access
Questions about rs2136135
What is rs2136135?
rs2136135 is a single position in the genome, in or near the near TINAG gene. Published research associates it with drinks per week. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2136135 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2136135 come from?
GWAS Catalog, Nature 2022, PMID:36477530. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Drinks per week (rs2136135). MyGeneLog™. https://www.mygenelog.com/variants/rs2136135
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