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Who was studied 77,627 European ancestry cases, 933,894 European ancestry controls.
The effect
Each copy of the A allele carried 1.06 times the odds of Gout (95% confidence interval 1.04-1.07); p = 1 × 10−12.
How common The A allele had a frequency of about 84% in the people studied.
Where it sits Chromosome 1, band 1p33 — between genes, 1.4 kb from SLC5A9.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Gout compared to the general population.
A/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Gout.
T/TPublished research associates this genotype with typical/baseline likelihood of Gout — no copies of the reported risk allele.
rs212986 is a single position in the genome, in or near the near SLC5A9 gene. Published research associates it with gout. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs212986 linked to?
On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.
Does having rs212986 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs212986 come from?
GWAS Catalog, Nature genetics 2024, PMID:39406924. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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