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Heel bone mineral density

ATXN7L1 · rs212417

Where this position leads

Condition: Heel Bone Mineral Density

rs212417 Condition: Heel Bone Mineral Density Heel Bone Mineral Density Condition rs212417 rs212417 ATXN7L1

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Heel bone mineral density — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Heel bone mineral density.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Heel bone mineral density compared to the general population.
Source
Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis
Kemp JP, Morris JA, Medina-Gomez C, Forgetta V, Warrington NM, Youlten SE, Zheng J, Gregson CL, Grundberg E, Trajanoska K, Logan JG, Pollard AS
and 26 more — show all
Sparkes PC, Ghirardello EJ, Allen R, Leitch VD, Butterfield NC, Komla-Ebri D, Adoum AT, Curry KF, White JK, Kussy F, Greenlaw KM, Xu C, Harvey NC, Cooper C, Adams DJ, Greenwood CMT, Maurano MT, Kaptoge S, Rivadeneira F, Tobias JH, Croucher PI, Ackert-Bicknell CL, Bassett JHD, Williams GR, Richards JB, Evans DM
Nature genetics · 2017 · PMID 28869591 · open access

Questions about rs212417

What is rs212417?

rs212417 is a single position in the genome, in or near the ATXN7L1 gene. Published research associates it with heel bone mineral density. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs212417 linked to?

On MyGeneLog this position is linked to Heel Bone Mineral Density. The research behind each link, and its sources, are set out on that condition page.

Does having rs212417 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs212417 come from?

GWAS Catalog, Nat Genet 2017, PMID:28869591. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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