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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 887,490 European ancestry individuals (MTAG effective sample size boosted by neuroticism, depression and anxiety samples).
The effect
Each copy of the A allele shifted the measure 0.009 lower (95% confidence interval 0.007-0.011); p = 8 × 10−10.
Where it sits Chromosome 14, band 14q21.1 — in an intron of LRFN5.
What each result means
A/ATwo copies of the version the research linked to Irritable bowel syndrome (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Irritable bowel syndrome (MTAG). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Irritable bowel syndrome (MTAG). This is the starting point the study compared everyone against.
Journal of translational medicine · 2023 · PMID 37085903 · open access
Questions about rs2121708
What is rs2121708?
rs2121708 is a single position in the genome, in or near the LRFN5 gene. Published research associates it with irritable bowel syndrome (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2121708 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2121708 come from?
GWAS Catalog, Journal of translational medicine 2023, PMID:37085903. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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