C/CTwo copies of the C allele. The discovery study reported a per-copy effect rather than a separate figure for two copies, so this genotype is expected to track toward the lower end of the range found at this position, without a published number specific to it.
T/COne copy of the C allele. The GWAS Catalog's summary of this study reports a per-copy effect of about 0.29 units lower blood zinc (range 0.22-0.35) at genome-wide significance (p = 2 x 10^-18).
T/TNo copies of the C allele. In the discovery study (two cohorts, Australian and British adults), this genotype tracked with the higher end of the blood zinc range found at this position.
No guideline sets a zinc intake target from this genotype. Blood zinc is measured directly when it matters clinically.
rs2120019 is a single position in the genome, in or near the PPCDC gene. Published research associates it with blood zinc levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2120019 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2120019 come from?
Evans et al. 2013, Human Molecular Genetics — genome-wide association study of blood copper, selenium and zinc; two adult cohorts, Australia and UK. PMID 23720494. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.