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Who was studied 615 African ancestry cases, 2,560 African ancestry controls, 767 Admixed-American ancestry cases, 14,907 Admixed-American ancestry controls, 3,097 European ancestry cases, 2,077 European ancestry controls, 146 East or South Asian cases, 1,285 East or South Asian controls, 8 Middle-Eastern ancestry cases, 40 Middle-Eastern ancestry controls.
The effect
Each copy of the C allele carried 5.30 times the odds of Family history of Alzheimer's disease (95% confidence interval 3.51-8.0); p = 2 × 10−15.
Where it sits Chromosome 11, band 11q11 — between genes, 28.4 kb from TRIM48.
What each result means
C/CTwo copies of the version the research linked to Family history of Alzheimer's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Family history of Alzheimer's disease. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Family history of Alzheimer's disease. This is the starting point the study compared everyone against.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026 · PMID 41755704 · open access
Questions about rs2120001636
What is rs2120001636?
rs2120001636 is a single position in the genome, in or near the near TRIM48 gene. Published research associates it with family history of alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2120001636 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs2120001636 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2120001636 come from?
GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2026, PMID:41755704. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 22122215Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI2Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)0Others15Total22Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Family history of Alzheimer's disease (rs2120001636). MyGeneLog™. https://www.mygenelog.com/variants/rs2120001636